Natural structure and engineered architecture enables rapid cell access.
Myriad™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process. Myriad™ contains 151 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process [1,2,3,4]
Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development . Studies have shown that when present in a graft material, natural vascular channels lead to a denser and more rapidly forming capillary network . Myriad™ contains an extensive network of vascular channels within the natural ECM . The vascular channels provide immediate and specific vascular architecture to support migrating endothelial cells to establish new vasculature and a robust blood supply [2,5].
Representative image of residual vascular channels present in Myriad™ ECM following dye perfusion (left) . Vasularization of the ECM in vivo (right) .
Myriad™ is designed to be easy to customize for a wide range of anatomical sites and individual situations. It is strong, soft, drapable, and conforming. It rehydrates quickly, and is easy to handle, cut, suture or staple. Myriad™ helps to achieve surgical mastery in routine and more challenging repair and reinforcement procedures.
Endoform® ECM technology has been in clinical use for over 10 years and over 5 million devices have been used in a range of soft tissue repair procedures, including wounds, abdominal wall repair, plastics and reconstructive surgery. Endoform® is a leading ECM technology for soft tissue repair.
Myriad™ is indicated for both implant and dermal procedures. Myriad™ is designed for use by a range of surgical specialties, including plastics, general, vascular and podiatric surgeons.
Myriad™ is suitable for a wide range of plastic and reconstructive surgical procedures where soft tissue requires repair or reinforcement. The structure and biology of Myriad™ may also help healing in patients with impaired or compromised healing due to local or systemic factors.
1. Lun, S., et al., A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 2010. 31(16): p. 4517-29. 2. Irvine, S.M., et al., Quantification of in vitro and in vivo. angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 2011. 32(27): p. 6351-61. 2011;32(27):6351-61. 3. Sizeland, K.H., et al., Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering. ACS Biomater. Sci. Eng., 2017. 3(10): p. 2550–2558. 4. Dempsey, S.G., et al., Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 2019. 18(4): p. 1657-1668. 5. Greaves, N.S., et al., Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 2015. 10(1): p. e0113209. 6. Data on file.